Department of Immunology UPMC Hillman Cancer Center

VIGNALI Laboratory

Advancing Next Generation Immunotherapeutics

Investigating immune regulation in cancer, autoimmunity, and inflammatory disease to inform the next generation of immunotherapies.

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Vignali Lab

Mechanistic immunology with translational reach.

The Vignali Laboratory studies immune regulatory circuits that control tolerance, inflammation, and antitumor immunity. Our work connects mechanistic discovery with the development of next-generation immunotherapeutics.

New review on LAG3 checkpoint function

Yong Jiang, Dario A. A. Vignali and Haopeng Wang review LAG3 signalling, T cell regulation, and therapeutic mechanisms of action in Nature Reviews Immunology.

LAG3 checkpoint function and its mechanism of action in therapeutic targeting

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